Divergent requirements for fibroblast growth factor signaling in zebrafish maxillary barbel and caudal fin regeneration
نویسندگان
چکیده
منابع مشابه
19-P025 Bone dynamics during adult zebrafish caudal fin regeneration
Planaria possess a population of pluripotent adult stem cells called neoblasts, capable of differentiating into all cell types required to regenerate entire animals from almost any fragment. The regeneration of different fragments is catalogued in a body of classical experiments by many eminent scientists. Here, we endeavour to explore these classical observations and insights and combine them ...
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Adult zebrafish completely regenerate their caudal fins following partial amputation. Fin regrowth can easily be monitored in vivo and regenerating tissues can be used to study this dynamic developmental process. In this study we determined that fin regeneration is significantly affected by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Zebrafish caudal fins were partially amputated, a...
متن کاملShp2–Mitogen-Activated Protein Kinase Signaling Drives Proliferation during Zebrafish Embryo Caudal Fin Fold Regeneration
Regeneration of the zebrafish caudal fin following amputation occurs through wound healing, followed by formation of a blastema, which produces cells to replace the lost tissue in the final phase of regenerative outgrowth. We show that ptpn11a-/- ptpn11b-/- zebrafish embryos, lacking functional Shp2, fail to regenerate their caudal fin folds. Rescue experiments indicated that Shp2a has a functi...
متن کاملDevelopment and Regeneration of the Zebrafish Maxillary Barbel: A Novel Study System for Vertebrate Tissue Growth and Repair
BACKGROUND Barbels are integumentary sense organs found in fishes, reptiles and amphibians. The zebrafish, Danio rerio, develops paired nasal and maxillary barbels approximately one month post fertilization. Small in diameter and optically clear, these adult appendages offer a window on the development, maintenance and function of multiple cell types including skin cells, neural-crest derived p...
متن کاملTNF signaling and macrophages govern fin regeneration in zebrafish larvae
Macrophages are essential for appendage regeneration after amputation in regenerative species. The molecular mechanisms through which macrophages orchestrate blastema formation and regeneration are still unclear. Here, we use the genetically tractable and transparent zebrafish larvae to study the functions of polarized macrophage subsets during caudal fin regeneration. After caudal fin amputati...
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ژورنال
عنوان ژورنال: Development, Growth & Differentiation
سال: 2013
ISSN: 0012-1592
DOI: 10.1111/dgd.12035